Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation
Fig 5
Purkinje spike burst-pause dynamics facilitates VOR phase-reversal learning.
(A) VOR gain adaptation with (red curve) and without (green curve) Purkinje spike burst-pause dynamics during: VOR adaptation (first 10000 s), phase-reversal learning (subsequent 12000 s), and normal VOR restoration (remaining 12000 s). (B) Purkinje spike burst-pause dynamics provides fast learning reversibility, consistently with experimental recordings [2]. By contrast, phase-reversal VOR learning is impaired in the absence of Purkinje complex spiking. See S6 Fig for the time course of VOR phase-reversal learning.