Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation
Fig 4
Role of Purkinje spike burst-pause dynamics in VOR cerebellar adaptation.
(A) VOR gain and phase adaptation with (purple curve) and without (green curve) CF-evoked Purkinje spike burst-pause dynamics. VOR cerebellar adaptation starts with zero gain owing to the initial synaptic weights at PF and MVN afferents (Table 5). Purkinje spike burst-pause dynamics provides better VOR gain adaptation (in terms of both rate and precision) converging to gain values within [0.8–0.9] (S5 Fig), which are consistent with experimental data [40, 45, 46]. (B) Purkinje complex spiking allows a sparser weight distribution (with higher Kurtosis) to be learnt at MF-MVN synapses, with significantly lesser MF afferents needed for learning consolidation. (C) The model endowed with Purkinje complex spiking updates less MF afferents during learning consolidation but their synaptic range is fully exploited. (D) The averaged synaptic weight variations are more selective during the adaptive process in the presence of Purkinje spike burst-pause dynamics, yet the standard deviation remains equal.