Quantitative cell-based model predicts mechanical stress response of growing tumor spheroids over various growth conditions and cell lines
Fig 9
(A) Simulation snapshots of DCM cells within a scaled capsule model, for the cases of cells with a reference cortex stiffness (top) and a “stiff” cortex stiffness (bottom). The coloring is according to pressure (B) Internal cell pressure for deformable cells in a shrunk capsule for nominal cells and stiff cells, as function of distance to the capsule center. The stiff cell types show a gradient in cell pressure if moving from the spheroid center towards the edge (indicated by dashed red line), while a higher variability as compared to the softer types. Notice that like in the calibration simulations we use cells of equal volume prior to compression but the method can equally be applied to any prior volume distribution.