Quantitative cell-based model predicts mechanical stress response of growing tumor spheroids over various growth conditions and cell lines
Fig 7
(A-B) Detail of the time evolution of radius of the CT26 and FHI spheroid relative to its initial state.
Data from [12] shown for free growth and at p = 5 kPa. Runs with Model II are for free growth and for p = 5 kPa. In the CT26 cell line an additional model run is shown assuming a linear cell cycle progression function. In the FHI cell line the vertical line indicates the presumed changes in experimental conditions for free growth over time resulting in a lower surface growth (v1 → v2). The gray zones in the plots indicate the min-max values of the data.