Computation predicts rapidly adapting mechanotransduction currents cannot account for tactile encoding in Merkel cell-neurite complexes
Fig 5
The respective currents underlying the composite current at one modeled Merkel cell—Neurite terminal, for wildtype (panel A) and Atoh1CKO (panel B) mouse cases.
Interestingly, across both animal types, the SI current is larger than the RI current, even in the dynamic phase of the stimulus. As well, the USI current is larger than the RI current. In the Atoh1CKO case then, it is the USI current that is nearly entirely driving the response.