Proteome-scale relationships between local amino acid composition and protein fates and functions
Table 1
The life-cycle of proteins with high local composition of individual amino acids involves the coordinated regulation of translation efficiency, protein abundance, and protein half-life.
For each amino acid, trends in median values for nTE, protein abundance, and half-life upon enrichment (i.e. approaching higher percent compositions) of the given amino acid are indicated. “Higher” indicates that proteins in larger percent composition bins tend to have a larger median value compared to all other proteins, while “Lower” indicates that proteins in larger percent composition bins tend to have a larger median value compared to all other proteins. “Mixed” indicates amino acids for which multiple transitions are observed upon progressive compositional enrichment. Datasets without clear, statistically significant transition thresholds are also indicated (“n.s.”). Colors correspond to the colors used in Figs 3–5.