Transmission of temporally correlated spike trains through synapses with short-term depression
Fig 1
Vesicle occupancy and neurotransmitter release rate are a function of the ISI distribution.
(A) Presynaptic spike train, vesicle occupancy and neurotransmitter release time-course for gamma-distributed ISIs with α as marked (in panel B) for the same release probabilty p = 0.6, presynaptic rate r = 5Hz and postsynaptic rate λ = 2Hz. (B) Corresponding ISI distributions for the three α values. (C) The cumulative distribution. (D) The mean 〈x〉 (grey) and the pre-spike 〈x〉∞ (black) release-site occupancies (Eqs 9 and 10). Note that 〈x〉∞ increases with increasing regularity, larger α. (E) Variance of the two occupancies exhibiting non-monotonic behaviour. (F) The mean neurotransmitter release rate 〈χ〉 is directly proportional to 〈x〉∞ and so shares its qualitative dependence on α. The code used to generate this figure is provided in the Supporting Material.