Reversing allosteric communication: From detecting allosteric sites to inducing and tuning targeted allosteric response
Fig 10
Fine-tuning of the allosteric response.
Fine-tuning of allosteric response at the NAD functional site of the NAD-dependent malic enzyme can be achieved by varying composition of the perturbed site 1. The free energy changes (kcal/mol) at the NAD functional site are shown. The black lines indicate possible structures of ligand frameworks that can interact with corresponding allosteric sites.