Reversing allosteric communication: From detecting allosteric sites to inducing and tuning targeted allosteric response
Fig 9
Inducing the allosteric response in the NADME.
Left: reverse perturbation of allosteric communication in the NADME revealed presence of the repertoire of potential latent allosteric sites. Right: sites 1–5 are perturbed and the resulted free energy changes at functional NAD site are tabulated. Site 5 serves as a negative control.