Reversing allosteric communication: From detecting allosteric sites to inducing and tuning targeted allosteric response
Fig 5
Results of the reverse perturbation of allosteric communication in the large BGDH and G6PD homohexamers.
Reverse perturbation of the allosteric communication suggested the presence of latent allosteric sites in the antenna region of the BGDH (A) and various locations of the G6PD (B). The antenna region of BGDH and the Cys219 in the core of G6PD are highlighted by circles in the free energy profiles. The large standard deviation of the per-residue free energy change is caused by the structural asymmetry of homologous subunits.