Reversing allosteric communication: From detecting allosteric sites to inducing and tuning targeted allosteric response
Fig 4
Free energy profiles obtained as a result of the reverse perturbation for PTP1B, SSUPRT and ThrS.
(A) PTP1B, a monomeric enzyme that regulates the insulin signalling pathway. (B) SSUPRT, a homotetramer that catalyzes the synthesis of uridine monophosphate. (C) ThrS, a homodimer for the biosynthesis of threonine.