Reversing allosteric communication: From detecting allosteric sites to inducing and tuning targeted allosteric response
Fig 3
Free energy profiles obtained as a result of the reverse perturbation for DAK, NADME, PFK and PGDH.
(A) DAK, a dimeric arginine kinase. (B) NADME, a homotetramer for oxidative decarboxylation of malate to pyruvate. (C) PFK, the homotetramer is a key enzyme in glycolytic pathway. (D) PGDH, a homotetramer involved in the biosynthesis of serine.