Predicting 3D structure and stability of RNA pseudoknots in monovalent and divalent ion solutions
Fig 7
The predicted thermal unfolding of MMTV, T2 and T2 variant pseudoknots at 1M [K+].
(a-c) The fractions of F, S1, S2 and U states as functions of temperature in thermal unfolding of MMTV (a), T2 (b), and T2 variant (c) pseudoknots at 1M [K+]. F stands for fully folded RNA; S1, hairpin intermediate with Stem 1; S2, hairpin intermediate with Stem 2; U, fully unfolded RNA. (d) Schematic diagram shows the dominating structural transitions of MMTV pseudoknot along the unfolding pathway inferred from the fraction of states shown in panel (a). (e) Schematic diagram shows the structural transitions of T2 pseudoknot and the variant of T2 pseudoknot along the unfolding pathway inferred from their respective fraction of states shown in panels (b) and (c).