Control of neurite growth and guidance by an inhibitory cell-body signal
Fig 4
Coupled growth and gradient detection.
The motifs depicted in Fig 3A and 3C are coupled together in a two-compartment model of a neurite. Activated receptors A are retrogradely transported from the growth cone to cell body to form a population Ac, and the inhibitory signal I is anterogradely transported to the growth cone to form a copy Ig. The output of the cell-body compartment F* regulates the supply of the substrate G at the growth cone.