Quantitative theory of deep brain stimulation of the subthalamic nucleus for the suppression of pathological rhythms in Parkinson’s disease
Fig 2
Effects of external pulse train stimulus on population activity.
(a) An example evoked response time series for an external pulse frequency fstim = 130 Hz, pulse width twidth = 130 ms, and coupling strength νax = 10 mV s. (b) Impulse response for a unit input at t = 0 with decay and rise rate parameters, β = 200 s−1 and α = 50 s−1, respectively. (c) Evoked response potential of a given population to the external stimulus represented by the convolution of the impulse response with the stimulus time series. (d) The mean effect of a voltage perturbation evoked by an external stimulus on the distribution of firing rates with a population. Example parameters used are Qmax = 500 s−1, σ′ = 3.3 mm, and θa = 10 mV.