Network supporting contextual fear learning after dorsal hippocampal damage has increased dependence on retrosplenial cortex
Fig 1
Overview of the experimental design.
In Experiment 1, the rats underwent pre-training dHPC lesions and, after recovery, a CFC session. Half the sample underwent fear memory test 48 h later, whereas the other half was perfused 3 hours after CFC and had their brains processed and stained for pCREB protein. Thirty regions had their pCREB expression quantified and their pCREB inter-regional correlations computed. After thresholding the correlations, we analyzed the networks properties and compared them between the groups. Following network analysis, Experiments 2 and 3 employed double lesions to test if the network differences observed could be empirically supported.