Stochastic shielding and edge importance for Markov chains with timescale separation
Fig 10
Stochastic shielding and the power spectrum in the acetylcholine receptor model.
For a low concentration ([ACh] = 0.5 μM shown here), edge importance is reversed. Panel A shows that the majority of the power comes from the hidden edges at low frequencies (S5,6, blue trace) and from the visible edges at high frequencies (S3,4, red trace), just as we saw in the 3-state model under the case of edge importance reversal. The corresponding Gaussian model trajectories shown in Panel B illustrate that X5,6 (blue) is the best approximation to X, although it misses some the fluctuations captured by X3,4 (red).