Stochastic shielding and edge importance for Markov chains with timescale separation
Fig 9
Stochastic shielding and the power spectrum in the acetylcholine receptor model.
For a high concentration ([ACh] = 100 μM shown here), edge importance is not reversed. Panel A shows that the majority of the power comes from the visible edges at all frequencies (S3,4, red trace), in agreement with the usual edge importance ranking. The corresponding Gaussian model trajectories shown in Panel B illustrate that X3,4 is the best approximation to X, whereas the other approximation only captures average behavior.