Implications for human odor sensing revealed from the statistics of odorant-receptor interactions
Fig 2
Analysis of dose-response data for odorant-OR pairs.
Examples of fit using Eq 3 are shown for some odorant-receptor pairs: a. allyl phenylacetate−OR51L1 (B = 2.18, δSmax = 4.76, log10 K1/2 = −7.56, H = 0.7); b. androstenone−OR7D4 (B = 0.21, δSmax = 3.09, log10 K1/2 = −5.72, H = 1.4); c. geranyl acetate−OR14A16 Indel (B = 0.32, δSmax = 0.96, log10 K1/2 = −3.84, H = 6.6); d. eugenol−OR10G7 (B = 3.69, δSmax = 5.21, log10 K1/2 = −8.95, H = 0.3). e. Dose-response data for 22 odorant-OR pairs collapsed onto a universal curve, f = 10ξ/(1 + 10ξ), where f = δS/δSmax and ξ = Hlog10(CO/K1/2) (orange line). For clarity, only the data from 22 activating pairs are presented.