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Modeling the functions of condensin in chromosome shaping and segregation

Fig 2

(A) Asphericity as a function of the strength F_cond and the threshold distance Δ of inter-condensin attractions, with . (B) Asphericity as a function of the loop-holding force F_loop under three pairs of different parameters of the attractions. (C) Chromosome monomer density as a function of the distance from condensin at the points D and E shown in panel A. (D–G) Example of the configurations observed at the end of the simulations at each point of D–G shown in panel A. The blue line is the chromosome and the red points are condensins. All simulations are performed employing a single chromosome condition with the number of monomers N = 5000 and the number of loops M = 100.

doi: https://doi.org/10.1371/journal.pcbi.1006152.g002