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Structural organization and energy storage in crosslinked actin assemblies

Fig 3

Influence of the crosslinker’s mechanical and kinetic properties on the organization of the actin network.

(A-D) Organization of 135nm-long actin filaments at the end of the simulation (t = 50s) for different values of extensional stiffness κ_ext, torsional stiffness κ_tor, and breakage rate , as indicated above the figure. (E) Local nematic order parameter S_local as a function of the extensional stiffness κ_ext, with κ_tor = 10pN ⋅ nm ⋅ rad⁻¹ and . (F) Local nematic order parameter S_local as a function of the torsional stiffness κ_tor, with κ_ext = 0.1pN/nm and . (G) Local nematic order parameter S_local as a function of the strain-free breakage rate , with κ_tor = 10pN ⋅ nm and κ_ext = 1pN/nm. In (E-G), simulations were performed for filaments of various lengths: 81nm (blue), 135nm (red), 189nm (orange). For each simulation, the means of S_local were calculated from the data between t = 40s to 50s and the error bars indicate standard deviation over 10 simulations. S_local corresponding to the networks in panels (A-D) are identified by the red symbols with corresponding shapes.

doi: https://doi.org/10.1371/journal.pcbi.1006150.g003