Organization of the core respiratory network: Insights from optogenetic and modeling studies
Fig 16
Experimental setup for site-specific optogenetic stimulation of inhibitory neurons within the pre-BötC or BötC.
(A) Dorsal view of the in situ arterially perfused transgenic mouse brainstem-spinal cord preparation. (B) Representative examples of extracellular recordings of pre-I/I population activity in the pre-BötC and inspiratory activity recorded from the phrenic nerve. Each panel shows raw (lower trace) and integrated (upper trace) pre-BötC and PN nerve inspiratory discharge. Abbreviations: V4, 4th ventricle; IC, inferior colliculus; pre-BötC, pre-Bötzinger complex; BötC, Bötzinger complex; rVRG, rostral ventrolateral respiratory group.