Organization of the core respiratory network: Insights from optogenetic and modeling studies
Fig 13
Model performance vs. experimental data for responses to sustained stimulations of inhibitory neurons within the BötC.
(A and B) Model responses to sustained stimulation of inhibitory neurons within the pre-BötC with low-intensity (A; stimChR = 0.14) and higher intensity (B, stimChR = 0.18) stimulation. The timing of the stimulus is indicated with blue shading and dashed red lines. Output activity of all neuron populations in the model are shown. The oscillation frequency decreases maximally in A, and is fully suppressed in B, similar to our experimental results (Fig 7) (C). Increases of stimulation intensity reduced oscillation frequency and terminated inspiratory activity at the highest intensities examined, directionally similar to the experimental results shown in Fig 7C.