Identifying robust hysteresis in networks
Fig 4
Search for the best 5 node E2F-Rb network.
(a) Full 5 node E2F-Rb network with input S. We test 12 subnetworks, listed in Table (b), top, for robustness of partial path and full path resettable bistability and hysteresis. (b) Each of the 12 subnetworks contains the unmarked edges in (a). In addition, we either add one of the edges 7 or 8, and/or a subset of the pair of edges (2a, 2b). The second through fifth columns list the percentage of subgraphs in EPG(¬MD) satisfying indicated query. Top three results in each column are emphasized. Note that top three networks in first three queries agree. While the very best network under full path resettable bistability is the same as for full path hyesteresis, none of the top three networks for full path hysteresis has either edge 7 or the edge 8.