Assessing the public health impact of tolerance-based therapies with mathematical models
Fig 3
All pathogens become resistant to treatment for large coverage of the ROL treatment.
Fraction of the population infected by the resistant pathogen over the total infected population (A, E), and equilibrium values of the incidence (B, F), prevalence (C, G), fraction of mortality due to infection (D, H). These epidemiological measures are plotted against the fraction of the population that receives treatment. The effect of ROL is displayed in black, that of TOL and ROL in blue. TOL, which does not lead to resistance, is represented in red and is reproduced for comparison from Fig 2. Parameters for both acute and chronic infections are given in the Methods section.