Assessing the public health impact of tolerance-based therapies with mathematical models
Fig 2
Evaluation of the efficacy of TOL and ROL in acute and chronic infections.
Equilibrium values of the incidence (A, D), prevalence (B, E), and fraction of mortality due to infection (C, F), which normalizes the disease-induced mortality by the overall mortality. These epidemiological measures are plotted against the fraction of the population that receives treatment. The effect of TOL is displayed in light red, that of ROL in black, and that of TOL and ROL combined in blue. Parameters for both acute and chronic infections are given in the Methods section.