RosettaAntibodyDesign (RAbD): A general framework for computational antibody design
Fig 6
Computational benchmarking of the opt-dG antibody design protocol.
Recovery metrics on 60 antibodies for the opt-dG protocol (optimization of Rosetta interface energy) for each CDR that underwent GraftDesign in the RAbD design protocol. (A) %Recovered and %Sampled for each CDR length and cluster for the opt-E simulations. (B) Design risk ratios (DRR) for recovery of CDR length and cluster for the opt-dG simulations. 95% confidence intervals for the Risk Ratio statistics are calculated as described in Methods.