RosettaAntibodyDesign (RAbD): A general framework for computational antibody design
Fig 4
Computational benchmarking of the opt-E protocol.
Recovery metrics on 60 antibodies for the opt-E protocol (optimization of total Rosetta energy) for each CDR that underwent GraftDesign in the RAbD design protocol. (A) %Recovered and %Sampled for each CDR length and cluster for the opt-E simulations. (B) Design risk ratios (DRR) for recovery of CDR length and cluster for the opt-E simulations. 95% confidence intervals for the Risk Ratio statistics are calculated as described in Methods.