A loop-counting method for covariate-corrected low-rank biclustering of gene-expression and genome-wide association study data
Fig 10
Row-traces for the bicluster shown in Example-A.
This bicluster was found by running our algorithm on the data shown in Fig 4. Because we corrected for controls, we compare our original-data to the distribution we obtain under the null-hypothesis H0 (see Methods). On the left we show the row-trace as a function of iteration for the original-data (red) as well as each of the 256 random shuffles (blue). On the right we replot this same trace data, showing the 5th, 50th and 95th percentile (across iterations) of the H0 distribution. Because we are not correcting for any covariates, the column-traces are identical to the row-traces.