Correcting for batch effects in case-control microbiome studies
Fig 5
OTUs significant across CRC studies, but not within a given study.
Pooling data provides greater statistical power to detect subtle, yet consistent differences in OTU abundances across sample groups. 18 OTUs are labeled by their most resolved taxonomic annotation. Each OTU in this plot was not found to be significant within either Baxter or Zeller studies, but became significant after pooling the percentile-normalized datasets (q ≤ 0.05).