Optimal dynamic control approach in a multi-objective therapeutic scenario: Application to drug delivery in the treatment of prostate cancer
Fig 7
Comparison of the three therapeutic objectives between the optimal control strategy (salmon) and the pharmacokinetic/pharmacodynamic modeling approach (blue) for 1000 individuals.
A) Distribution of tcast (time to obtain testosterone levels below castration limit) values. B) Distribution of the values of the testosterone flare-up (maximum testosterone level/baseline testosterone level). C) Distribution of tcast + teffect (castration time after injection of the drug) time values of the modelling approach.