Effect of Ca2+ on the promiscuous target-protein binding of calmodulin
Fig 10
Representative models from the binding classes of apo C-CaM and N-CaM, with C-CaM intermediate binding to a) NaV1.6 ion channel and N-CaM shallow binding to b) Myosin VIIa.
Color-highlighted residues are hydrophobic residues showing distinct signals in the contact-solvent exposure analysis. The other hydrophobic residues are shown by the white mesh. Associated to each class is the average total solvent exposure distribution per state (upper row) and the average distribution of contact types formed in the CaM-complexes (lower row). The standard deviation is indicated on the bars.