Effect of Ca2+ on the promiscuous target-protein binding of calmodulin
Fig 8
Representative models from the three binding classes of holo C-CaM, with deep binding in c) olfactory cyclic nucleotide-gated ion channel (OLFp), intermediate binding in d) chimeric Kv7.2—Kv7.3 ion channel and shallow binding in e) EAG1 ion channel.
Color-highlighted residues are hydrophobic residues showing distinct signals in the contact-solvent exposure analysis. The other hydrophobic residues are shown by the white mesh. Associated to each class is a) the average total solvent exposure distribution per state and b) the average distribution of contact types formed in the CaM-complexes. The standard deviation is indicated on the bars.