Effect of Ca2+ on the promiscuous target-protein binding of calmodulin
Fig 5
a) N-CaM and b) C-CaM states (clusters) projected onto interhelical angles of apo CaM, colored by their respective assigned cluster.
The gray dots correspond to the holo ensemble. The white squares are experimentally determined structures of protein-unbound apo CaM, while pink squares are experimentally determined structures of protein-bound apo CaM. The black circles represent values of CaM interhelical angles inferred from NMR data [2, 24].