Effect of Ca2+ on the promiscuous target-protein binding of calmodulin
Fig 4
a) N-CaM and b) C-CaM states (clusters) projected onto interhelical angles of holo CaM, colored by their respective assigned cluster.
The gray dots correspond to the apo ensemble. The white squares are experimentally determined structures of protein-unbound holo CaM, while pink squares are experimentally determined structures of protein-bound holo CaM. The black circles respresent values of CaM interhelical angles inferred from NMR data [2, 24].