Activation gating in HCN2 channels
Fig 4
Effect of cAMP on the probability flux densities along the main pathways of activation from 0 mV to -130 mV and subsequent deactivation to -40 mV.
The time courses were computed with model 1n (no cAMP) or 1a (10 μM cAMP). The colors of the arrows in the top schemes correspond to the colors of the probability flux density time courses. The predominant effect of cAMP is to strongly accelerate the probability flux density of the activation pathway.