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Activation gating in HCN2 channels

Fig 2

Global fit of activation and deactivation time courses in either the absence or presence of cAMP.

(a) Scheme of model 1n. (b) Fit of the 27 time courses of activation and deactivation in the absence of cAMP. (c) Scheme of model 1a. (d) Fit of the 27 time courses of activation and deactivation in the presence of 10 μM cAMP. The experimental traces and fitted curves are given in black and red color, respectively. Shades of gray indicate s.e.m. The parameters are provided by Table 1.

Fig 2

doi: https://doi.org/10.1371/journal.pcbi.1006045.g002