Stoichiometric balance of protein copy numbers is measurable and functionally significant in a protein-protein interaction network for yeast endocytosis
Fig 6
Biological IIN topologies have more misinteractions under imbalance.
Shown are trends in misinteraction frequency under balanced concentrations (blue arrows) and sensitivity to imbalance (red arrows). Several features that make networks perform better under balanced concentrations make them perform worse under unbalanced concentrations: sparseness, a topology that matches with real interface networks, and a power-law degree distribution. Strong average binding caused both increased misinteractions and increased sensitivity.