Multiscale modeling of layer formation in epidermis
Fig 6
Selective cell adhesion significantly sharpens the boundaries between spinous and granular layers.
(A) A schematic diagram shows the selective cell adhesion mechanism. (B) Time course images of layer formation of Selective Adhesion Model. Black dashed lines represent the basement membrane. (C) Sharpness Index. Bar length represents the value of sharpness index at height in the unit of cell numbers. Red, green and blue stack bars represent the portion of basal, spinous and granular cells at height in the unit of cell numbers. (D) Isolation Ratio. Mean and standard deviation in 3D model is over an ensemble of 20 simulations. All the parameters used in the simulations are in Table A in S2 Text.