A multiscale modelling approach to assess the impact of metabolic zonation and microperfusion on the hepatic carbohydrate metabolism
Fig 7
Variations of the cellular glycogen content during a 48h fasting-refeeding cycle (A) Simulated glycogen content of individual hepatocytes along the liver sinusoid. Red line–PPH (cell#1), green line–PCH (cell#22). Experimental data (open circles) were taken from [25]. (B) Simulated mean hepatic glycogen content (black line) and standard deviation (grey-shaded area) in response to parameter variation (100 trials with random parameter sampling based on the parameter distribution functions shown in Fig 3D–3F). (C) Simulated distribution of glycogen content across individual hepatocytes over time.