A multiscale modelling approach to assess the impact of metabolic zonation and microperfusion on the hepatic carbohydrate metabolism
Fig 6
Glucose distribution at different spatial positions within the STU.
Mean values from 100 simulations with randomly sampled STUs are shown. The STU is made up by 22 hepatocytes arranged along a sinusoid with a length of 200 μm. Portal glucose concentrations were varied between 3 and 12 mM. The continuous lines were created by linear interpolation between the discrete values (one value per compartment) obtained in the model simulation. (A) Glucose concentration; (B) Glucose exchange fluxes; (C) Glucose concentration differences between the space of Disse and the sinusoid glucose gradient; (D) Glucose concentration differences between the space of Disse and hepatocytes.