A multiscale modelling approach to assess the impact of metabolic zonation and microperfusion on the hepatic carbohydrate metabolism
Fig 3
Effect of variations of tissue parameter on indicator dilution curves Simulations were run 100 times with random structural parameter sampling.
Sampled parameters include portal-central pressure difference, blood vessel diameter, thickness of space of Disse, hepatocyte radius, cell number along the sinusoid, degree of fenestration. (A) indicator dilution curve for labeled red blood cells; (B) indicator dilution curve for labeled albumin; (C) indicator dilution curve for labeled water. Crosses depict experimental data taken from [38], black line represents the mean of 100 simulations, gray shaded areas represent standard deviations. Parameter distribution for portal-central pressure difference (D), blood vessel diameter (E) and thickness of space of Disse (F). Data taken from [39–41].