Trade-off between synergy and efficacy in combinations of HIV-1 latency-reversing agents
Fig 8
The synergy-efficacy trade-off.
(A) The contours of constant fon (Fig 6A) superimposed on the synergy heatmap (Fig 6B). (B) The maximum synergy as a function of fon demonstrating the synergy-efficacy trade-off (symbols). The line is a quadratic fit to guide the eye. (C) The values of ϕPKCa and ϕHDACi that maximize β as functions of fon and (D) the associated drug concentrations estimated using the dose-response curves (Figs 3 and 4).