Trade-off between synergy and efficacy in combinations of HIV-1 latency-reversing agents
Fig 5
Co-stimulation with PKC agonists and HDACi’s.
The fraction of cells reactivated, fon, following simultaneous exposure to 1 nM (blue) or 10 nM (red) bryostatin-1 and (A) VPA, (B) NaBut, and (C) TSA, observed experimentally [33] (symbols) and predicted by our simulations (lines). The values of ϕPKCa and ϕHDACi corresponding to the individual drug concentrations employed were obtained from the dose-response curves in Figs 3 and 4, respectively. Simulations based on confidence limits on these parameter values yielded 95% confidence limits on our predictions (shaded regions). All the other parameters are in Table 1.