Memory functions reveal structural properties of gene regulatory networks
Fig 5
Olig2 repression of Pax6 increases robustness to initial conditions.
(A) Patterning without the repressive link from Olig2 to Pax6, showing steady states reached from standard initial conditions. Compared to the full network, the qualitative domain structure is conserved. (B) Patterning for the full network for initial conditions with high levels of Pax6 and Irx3 is qualitatively identical to low initial levels of Pax6 and Irx3. Initial conditions [Pax6] = [Irx3] = 1. (C) Patterning without the repressive link from Olig2 to Pax6 for initial conditions with high levels of Pax6 and Irx3. The p3 domain is lost as a consequence of the different initial conditions. (D) Bifurcation diagram of the network without Olig2-Pax6 repression. The region in which the pMN state (Olig2 high) is stable has expanded ventrally, thus making the ventralmost region bistable.