Hub connectivity, neuronal diversity, and gene expression in the Caenorhabditis elegans connectome
Fig 5
Rich-club organization of the C. elegans connectome.
(A) Degree distribution of neurons, labeled to four categories: (i) interneuron (85 neurons, orange), (ii) motor (108 neurons, green), (iii) sensory (68 neurons, blue), or (iv) multiple assignments (18 neurons, yellow). The distribution features an extended tail of high-degree interneurons. (B) Normalized rich club coefficient, Φnorm (red), as a function of the degree, k, at which hubs are defined (as neurons with degree > k). Also shown is the mean Euclidean separation distance, d (purple) between connected hub regions (across degree thresholds, k). Φnorm > 1 indicates that hubs are more densely interconnected among each other than expected by chance, with red circles indicating values of Φnorm that are significantly higher than an ensemble of 1 000 degree-matched null networks (p < 0.05). Purple circles indicate where the Euclidean distance between connected pairs of hubs is significantly greater than the Euclidean distance for all other pairs of connected regions (right-tailed Welch’s t-test, p < 0.05).