A mechanistic pan-cancer pathway model informed by multi-omics data interprets stochastic cell fate responses to drugs and mitogens
Fig 1
A) Cartoon schematic of the single-cell pan-cancer driver network model. RTK, proliferation and growth, cell cycle, apoptosis, DNA damage, and gene expression submodels, with genes, compartments (capitalized italic) and general interactions indicated (light blue lines). Detailed kinetic mechanisms are in S1 Fig). B) We first evaluate individual submodel behavior (unit testing), followed by integrated unit testing of all submodels together. We then use the model to reason about biological observations.