Systems-level computational modeling demonstrates fuel selection switching in high capacity running and low capacity running rats
Fig 12
Simulated estimation of HCR and LCR fatty acid oxidation capacity.
To theoretically assess FA utilization capacity in HCR (blue) and LCR (red), glycolytic enzyme activities were decreased by several orders of magnitude to eliminate ATP synthesis from glucose. (A) Average ATP concentration at increasing ATPase rates. (B) Average mitochondrial adenine nucleotide transporter (ANT) flux at increasing ATPase rates. (C) Average of β-oxidation enzyme fluxes at increasing ATPase rates. The error bars represent standard deviations from 10 families of HCR and LCR activity parameter sets (Fig 7).