Systems-level computational modeling demonstrates fuel selection switching in high capacity running and low capacity running rats
Fig 11
Median HCR and LCR normalized enzyme activity scores.
HCR and LCR enzyme activities, each from 103 parameter sets, and their corresponding sensitivity coefficients, were used to calculate a median enzyme activity score to assess each enzyme’s importance in fuel selection. HCR scores are depicted by blue bars and LCR by red bars. Enzyme activity scores are labeled by shortened identifiers, described in S1 Table, and further grouped with brackets into major pathways defined in Fig 1. (Inset) Zoomed in view of certain beta-oxidation enzyme activity scores. Error bars represent standard deviations.