Systems-level computational modeling demonstrates fuel selection switching in high capacity running and low capacity running rats
Fig 9
Histograms of HCR enzyme activity (XHCR) sensitivities to fuel selection ranked from multiple HCR parameter sets.
A 103 parameter sets, each composed of 86 enzyme activities, individually fitted to HCR were used to obtain 103 sensitivity coefficients for each activity. Each histogram panel in the figure represents a distribution of one of the 86 enzyme activity sensitivity coefficients. Each panel is annotated per the shortened enzyme identifier defined in S1 Table. In each histogram panel, the y-axis represents the observed occurrence, or frequency, of a sensitivity coefficient and the x-axis represents the rank, or order of sensitivity coefficient magnitude out of 86. For instance, rank 1 is the most sensitive activity (XHCR) whereas as rank 86 is the least sensitive activity. Histogram panels are ordered per their median rank value from top left to bottom right in the figure. Thus, the most sensitive activities are ordered from top left to bottom right in the figure.